Allosteric Modulation of Estrogen Receptor Conformation by Different Estrogen Response Elements
نویسندگان
چکیده
منابع مشابه
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.
Hormone-activated ERs (ERalpha and ERbeta) bind with high affinity to specific DNA sequences, estrogen response elements (EREs), located within the regulatory regions of target genes. Once considered to function solely as receptor tethers, there is an increasing amount of recent evidence to suggest that the sequence of the ERE can influence receptor activity. In this study, we have performed a ...
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The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the steroid/nuclear receptor superfamily. Two genes encode mammalian ER: ERalpha and ERbeta. ER binds to specific DNA sequences called estrogen response elements (EREs) with high affinity and transactivates gene expression in response to estradiol (E(2)). The purpose of this review is to summarize how natural ...
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The existence of two rather than one estrogen receptor, today characterized as estrogen receptor a (ERa) and estrogen receptor b (ERb), indicates that the mechanism of action of 17b-estradiol and related synthetic drugs is more complex than previously thought. Because the homology of amino acid residues in the ligand-binding domain (LBD) of ERb is high compared with those amino acid residues in...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2001
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.15.7.0671